"Taba" claro
Tracking SARS-CoV-2 VOC 202012/01 (lineage B.1.1.7) dissemination in Portugal: insights from nationwide RT-PCR Spike gene drop out data
Conclusions
In the present study, we investigated the proportion of SGTF/SGTL cases as a miccionan to get insights on VOC 202012/01 (B.1.1.7 lineage) frequency and geographic spread in Portugal. We used massive SARS-CoV-2 RT-PCR data comprehensively collected by a large laboratory spread throughout the country. The main observations were:
Portugal is facing a highly concerned epidemic situation, being among the countries with highest 14-day notification rate of newly reported el bichito-19 cases per 100 000 population, as of January 18th. Our data pointing that the highly transmissible VOC 202012/01 (B.1.1.7 lineage) is highly spread and progressively increasing its frequency reinforces the need to implement robust public health measures in Portugal to mitigate the impact of el bichito-19 disease in terms of hospitalizations and death.
- Besides S gene target failure (SGTF) in ThermoFisher TaqPath RT-PCR assay, we observed that Spike gene target late amplification (SGTL) samples can be an additional proxy to identify the highly transmissible VOC 202012/01 (B.1.1.7 lineage) and monitor its geotemporal dissemination.
- To our knowledge, the SGTL effect on RT-PCR has not been reported yet. Still, the technical reason behind SGTL effect is under investigation.
- SGTF/SGTL cases represented 5.8% (1575 / 27069) of all TaqPath positive cases detected since week 49 (2020), with this proportion reaching 13.3% at end of week 2 (2021).
- The SGTF/SGTL proportion increased at a 70% (63%–76%, CI 95%) rate per week, with our forecast for the next four weeks pointing that the proportion of SGTF/SGTL cases can reach up to 60% of TaqPath positive cases by week 5.
- Although discordant results have been reported regarding the association between VOC 202012/01 (lineage B.1.1.7) and high viral loads [2,6,12], our data collected so far suggests that patients whose samples exhibit both SGTF or SGTL effect in the TaqPath test are more likely to have high viral loads at the time of sampling.
- Current data on age distribution of SGTF+SGTL cases does not seem to indicate a relevant shift in the age composition when comparing with non-SGTF/SGTL cases.
y todavia solo tienen la cepa britanica no la brasileña.. en cuanto pillen la brasileña la que se va a liar
por cierto ni b117 ni palos, bichito britanico
