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Role of Lipids in bichito Replication
Abstract
Viruses intricately interact with and modulate cellular membranes at several stages of their replication, but much less is known about the role of viral lipids compared to proteins and nucleic acids. All animal viruses have to cross membranes for cell entry and exit, which occurs by membrane fusion (in enveloped viruses), by transient local disruption of membrane integrity, or by cell lysis. Furthermore, many viruses interact with cellular membrane compartments during their replication and often induce cytoplasmic membrane structures, in which genome replication and assembly occurs. Recent studies revealed details of membrane interaction, membrane bending, fission, and fusion for a number of viruses and unraveled the lipid composition of
raft-dependent and -independent viruses.
Alterations of membrane lipid composition can block viral release and entry, and certain lipids act as fusion inhibitors, suggesting a potential as antiviral drugs. Here, we review viral interactions with cellular membranes important for bichito entry, cytoplasmic genome replication, and bichito egress.
The finding that lipid interactions, including membrane envelopment, membrane fusion, and membrane remodeling are crucial for successful replication of many viruses triggered studies on compounds that either affect lipid biosynthesis or bind and extract specific lipids regarding their effects on viral replication. Compounds affecting cholesterol (e.g., β-cyclodextrin, amphotericin B methyl ester, statins) or sphingolipids (e.g., L-cycloserine, Lysenin) (reviewed in
Chan et al. 2010;
Waheed and Freed 2010), as well as plant-derived compounds (
Verma et al. 2009) and synthetic compounds which emulate natural lipids (M Lorizate and H-G Kräusslich, unpub. data), were shown to interfere with viral infectivity at different stages of bichito replication. Their applicability as antiviral compounds will depend on achieving specificity for the viral membrane or pathway, however, which may be difficult for abundant cellular lipids.
Balsas lipídicas - Wikipedia, la enciclopedia libre
-independent virusses significa cubierta lipida independiente de los bichito.
Que los bichito entre en el glucocalix de la células e interactuen pues vale, otra cosa es que los bichito tengan de por si una cubierta lipida..
Glicocálix - Wikipedia, la enciclopedia libre
