Se refiere a esta prueba:
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
- Vineet D Menachery,
- Boyd L Yount Jr,
- Kari Debbink,
- Sudhakar Agnihothram,
- Lisa E Gralinski,
- Jessica A Plante,
- Rachel L Graham,
- Trevor Scobey,
- Xing-Yi Ge, (<=== señalado en 4chan)
- Eric F Donaldson,
- Scott H Randell,
- Antonio Lanzavecchia,
- Wayne A Marasco, (<=== investigador de Dana Farber)
- Zhengli-Li Shi &
- Ralph S Baric
Abstract
The emergence of severe acute respiratory syndrome cobi19 (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like bichito, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations
1. Using the SARS-CoV reverse genetics system
2, we
generated and characterized a chimeric bichito expressing the spike of bat cobi19 SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently
use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally,
in vivo experiments demonstrate replication of
the chimeric bichito in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy;
both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant bichito and demonstrate robust viral replication both
in vitro and
in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.
En 2015 ya tenían un bichito que in vitro dañaba los pulmones humanos y en ratones desarrollaba patogénesis.
También conocían la proteína de la immunodeficiencia desde 2016:
Bat SARS-like cobi19 WIV1 encodes an extra accessory protein ORFX involved in modulation of host immune response | Request PDF
Aquí en 4chan descubren que el bichito SARS-CoV-2 comparte exactamente la misma proteina de la membran que el original, imposible si surge a base de mutaciones naturales:
Está claro que es un bichito diseñado en laboratorio. Lo que está por ver es si los chinos la han cagado o alguien lo ha soltado. Ahí arriba dicen que los operarios de los laboratorios encargados de quemar los murciélagos, para sacarse un dinero extra los vendieron en el mercado de Wuhan ...
