BAXTER: cepas de gripe humana contaminados con el H5N1

Baxter: Product contained live bird flu bichito

By Helen Branswell, THE CANADIAN PRESS
Last Updated: 27th February 2009, 3:26pm



The company that released contaminated flu bichito material from a plant in Austria confirmed Friday that the experimental product contained live H5N1 avian flu viruses.
And an official of the World Health Organization’s European operation said the body is closely monitoring the investigation into the events that took place at Baxter International’s research facility in Orth-Donau, Austria.
“At this juncture we are confident in saying that public health and occupational risk is minimal at present,” medical officer Roberta Andraghetti said from Copenhagen, Denmark.
“But what remains unanswered are the circumstances surrounding the incident in the Baxter facility in Orth-Donau.”
The contaminated product, a mix of H3N2 seasonal flu viruses and unlabelled H5N1 viruses, was supplied to an Austrian research company. The Austrian firm, Avir Green Hills Biotechnology, then sent portions of it to sub-contractors in the Czech Republic, Slovenia and Germany.
The contamination incident, which is being investigated by the four European countries, came to light when the subcontractor in the Czech Republic inoculated ferrets with the product and they died. Ferrets shouldn’t die from exposure to human H3N2 flu viruses.
Public health authorities concerned about what has been described as a “serious error” on Baxter’s part have assumed the death of the ferrets meant the H5N1 bichito in the product was live. But the company, Baxter International Inc., has been parsimonious about the amount of information it has released about the event.
On Friday, the company’s director of global bioscience communications confirmed what scientists have suspected.
“It was live,” Christopher Bona said in an email.
The contaminated product, which Baxter calls “experimental bichito material,” was made at the Orth-Donau research facility. Baxter makes its flu vaccine — including a human H5N1 vaccine for which a licence is expected shortly — at a facility in the Czech Republic.
People familiar with biosecurity rules are dismayed by evidence that human H3N2 and avian H5N1 viruses somehow co-mingled in the Orth-Donau facility. That is a dangerous practice that should not be allowed to happen, a number of experts insisted.
Accidental release of a mixture of live H5N1 and H3N2 viruses could have resulted in dire consequences.
While H5N1 doesn’t easily infect people, H3N2 viruses do. If someone exposed to a mixture of the two had been simultaneously infected with both strains, he or she could have served as an incubator for a hybrid bichito able to transmit easily to and among people.
That mixing process, called reassortment, is one of two ways pandemic viruses are created.
There is no suggestion that happened because of this accident, however.
“We have no evidence of any reassortment, that any reassortment may have occurred,” said Andraghetti.
“And we have no evidence of any increased transmissibility of the viruses that were involved in the experiment with the ferrets in the Czech Republic.”
Baxter hasn’t shed much light — at least not publicly — on how the accident happened. Earlier this week Bona called the mistake the result of a combination of “just the process itself, (and) technical and human error in this procedure.”
He said he couldn’t reveal more information because it would give away proprietary information about Baxter’s production process.
Andraghetti said Friday the four investigating governments are co-operating closely with the WHO and the European Centre for Disease Control in Stockholm, Sweden.
“We are in very close contact with Austrian authorities to understand what the circumstances of the incident in their laboratory were,” she said.
“And the reason for us wishing to know what has happened is to prevent similar events in the future and to share lessons that can be learned from this event with others to prevent similar events. ... This is very important.”

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Doomsday dijo:

La farmaceutica BAXTER envio a material experimental contaminado por el bichito de la gripe aviar H5N1. El material contaminado era el de la gripe humana el cual mezclado con el de la gripe aviar podria crear una variante de facil transmision entre humanos. La noticia sale publicada en un periodico canandiense pero como siempre es algo que pasa desapercibido para la poblacion. La verdad es que esto empieza a dar miedo ya que segun expertos en biotecnologia, que se produzca esta contaminacion de forma fortuita en laboratorios con tan alta seguridad es completamente imposible.



Baxter: Product contained live bird flu bichito | Canada | News | Toronto Sun
?Accidental? Contamination Of Vaccine With Live Avian Flu bichito Virtually Impossible
Baxter: Product contained live bird flu bichito

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Then a granite company outside of Nuberg, Georgia was approached by a mysterious stranger who called himself "R.C. Christian," which he admitted was a fake name.

The Georgia Guidestones.

The stranger wanted a Stonehenge built -- he had a model of it in a shoe box -- and had selected Nuberg because it was remote and because it offered good granite. Mr. Christian reportedly left $50,000 in a local bank, told the locals that they would never see him again, and vanished forever...
(...)
The main cluster was completed on March 22, 1980, using granite quarried from nearby Elberton.

On the top stone, carved on the four sides in Egyptian Hieroglyphics, Classical Greek, Sanskrit, and Babylonian Cuneiform, it says: ""Let these be Guidestones to an Age of Reason."

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Berlín, 2 de marzo, RIA Novosti. Un habitante de la ciudad de Gifhorn (Baja Sajonia) llamó a la comisaría la noche pasada, declarando que en su casa llegaron extraterrestres que hablaban en ruso, informó hoy la policía local.

Un hombre de 40 años llamó a las 03.30 a la comisaría, afirmando que en su apartamento estaban volando seis seres extraterrestres, con estatura de unos 15 centímeros, que estaban conversando en ruso con él, dijo un portavoz de la policía, sin concretar si el propio inquilino hablaba el ruso o no.

A los policías que acudieron al lugar del incidente, el individuo les dijo que los alienígenas ya habían salido afuera por la puerta y probablemente se escondían en las macetas.

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Asdrúbal el Bello dijo:

Para paranoia esta:

RIA Novosti - Últimas noticias - Alemán afirma que lo visitaron extraterrestres que hablaban en ruso[/QUOTE
No sabía que los duendes hablaran ruso...

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Asdrúbal el Bello dijo:

Para paranoia esta:

RIA Novosti - Últimas noticias - Alemán afirma que lo visitaron extraterrestres que hablaban en ruso

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allseeyingeye dijo:

bueno bueno, olvidemos de los rusos cosmonautas, y volvamos al asunto....


En la noticia ya lo recuerdan, que no es la primera vez que pasa, que BAYER ya hizo lo mismo pero con bichito del SIDA (sea lo que sea eso).


Es muuuu rellenito el asunto.

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La compañía que libero material contaminado con bichito de influenza desde una planta en Austria, confirmó el viernes, que el producto experimental contenía bichito de la influenza aviar H5N1. Y una oficial de la operación europea de la OMS dijo, que la organización monitorea de cerca la investigación de los hechos que tomaron lugar en un centro de investigación de Baxter en Orth-Donau, Austria.
“En este punto, estamos confiados en decir que la salud pública y el riesgo ocupacional, hoy es mínimo” dijo la oficial Roberta Andraghetti en Copenhagen, Dinamarca
“Pero lo que permanece sin contestar, son las circunstancias que rodean al incidente en el complejo de la Baxter en Orth-Donau.”
El producto contaminado, una mezcla de H3N2 un bichito estacional de influenza y bichito H5N1 sin etiquetar que fue entregado a una compañía Austriaca de investigación. La firma Austriaca Biotecnológica Avir Green Hills, entonces envió porciones de esta a subcontratistas en la República Checa, Eslovenia y Alemania.
El incidente de contaminación, el cual está siendo investigando por los cuatro países europeos, fue descubierto cuando los subcontratistas en de la República Checa inocularon hurones con el producto y murieron. Los hurones no deberían haber muerto por la exposición al bichito de influenza H3N2.
Las autoridades públicas de salud están preocupadas, por lo que ha sido descrito como un “grave error” de parte de Baxter, quienes han asumido que la muerte de los hurones significa que el bichito H5N1 en el producto estaba vivo. Pero la compañía Baxter Internacional Inc., ha sido parsimoniosa en cuanto a la cantidad de información que ha liberado acerca del evento.
El viernes, el director global de comunicaciones de biociencia de la compañía, confirmo lo que los científicos sospechaban.
“Estaba Vivo” dijo Chistopher Bona en un email.
El producto contaminado, el cual Baxter llama “material viral experimental”, fue hecho en el complejo de investigación de Orth-Donau. Baxter hace su banderilla para la influenza ---incluyendo una banderilla para humanos de H5N1 por la cual una patente se espera en poco tiempo--- en un complejo en la República Checa.
La gente que está familiarizada con las reglas bioseguridad están alarmados por la evidencia que los bichito H3N2 humano y H5N1 aviar de alguna forma se hayan mezclado en el complejo de Orth-Donau. Esa es una práctica peligrosa la cual no debió haberse permitido que ocurriera., insisten numerosos expertos.
La entrega accidental de mezcla de bichito H5N1 vivo y bichito H3N2, pudo haber resultado en graves consecuencias.
Mientras que el H5N1 no infecta fácilmente a las personas, el H3N2 sí. Si alguien es expuesto a una mezcla de los dos y es infectado en forma simultánea con las dos cepas, él o ella, hubiese servido como incubadora para un bichito hibrido, capaz de transmitirse fácilmente ha y entre personas.
Ese proceso de mezcla llamado “reassortment”, es una de las dos formas en las cuales un bichito pandémico es creado.
De cualquier forma, no hay sugerencias de que esto haya sucedido por el accidente.
“No tenemos evidencia de que algún “reassortment”, o cualquier “reassortment" tal vez haya ocurrido” dijo Andraghetti.
“Y no tenemos ninguna evidencia de cualquier aumento en la transmisibilidad del bichito que hubiese estado envuelta en el experimento con los hurones en la República Checa”
Baxter no ha dado muchas luces ---al menos no públicamente---en como ocurrió el accidente. A comienzos de esta semana Bona llamó al error como una combinación de “El proceso en sí, (y) error técnico y humano en el procedimiento”
El dijo que no podía revelar más información debido a que podría revelar información privilegiada sobre procesos productivos de Baxter.
Andraghetti dijo el viernes que los cuatro gobiernos que investigan están cooperando en conjunto con la OMS y el Centro Europeo de Control de Enfermedades en Estocolmo Suecia.
“Estamos en contacto muy cercano con las autoridades austriacas para entender cuáles fueron las circunstancias del incidente en sus laboratorios”, ella dijo.
“Y la razón por la cual deseamos saber que fue lo que paso es el prevenir eventos similares en el futuro y compartir lecciones las cuales puedan ser aprendidas de este suceso con otros para prevenir que algo similar vuelva a ocurrir….esto es muy importante”

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• Baxter no está siguiendo las normas de seguridad BSL3 o es tan descuidado en el seguimiento que puede cometer errores monumentales que ponen en peligro la seguridad de toda la raza humana.
• Alguien coloca el bichito intencionadamente en materiales de banderilla con la esperanza de que tales materiales puedan ser inyectados en seres humanos y de inicio a una esa época en el 2020 de la que yo le hablo mundial de gripe aviar.

New bird flu cases suggest the danger of pandemic is rising

Infections in Egypt raise scientists' antiestéticars that bichito will be spread by humans
<author> By Geoffrey Lean, Environment Editor </author>

Sunday, 12 April 2009


REUTERS
Chickens for sale in Cairo: Most bird-flu victims in Egypt this year are children

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First the good news: bird flu is becoming less deadly. Now the bad: scientists antiestéticar that this is the very thing that could make the bichito more able to cause a pandemic that would kill hundreds of millions of people.
This paradox – emerging from Egypt, the most recent epicentre of the disease – threatens to increase the disease's ability to spread from person to person by helping it achieve the crucial mutation in the bichito which could turn it into the greatest plague to hit Britain since the Black Death. Last year the Government identified the bird-flu bichito, codenamed H5N1, as the biggest threat facing the country – with the potential to kill up to 750,000 Britons.
The World Health Organisation is to back an investigation into a change in the pattern of the disease in Egypt, the most seriously affected country outside Asia. Although infections have been on the rise this year, with three more reported last week, they have almost all been in children under the age of three, while 12 months ago it was mainly adults and older children who were affected. And the infections have been much milder than usual; the disease normally kills more than half of those affected; all of the 11 Egyptians so far infected this year are still alive.
Experts say that these developments make it more likely that the bichito will spread. Ironically, its very virulence has provided an important safeguard. It did not get much chance to infect other people when it killed its victims swiftly, but now it has much more of a chance to mutate and be passed on.
The WHO antiestéticars that this year's rise in infections among small children, without similar cases being seen in older people, raises questions about whether adults are being infected but not falling ill, so acting as symptomless carriers of the disease. Its investigation, due to start this summer, will see if this is happening by testing the blood of people who may have been in contact with infected birds, but who have not themselves become sick.
John Jabbour, who works with WHO in Cairo, told Reuters last week: "There is something strange happening in Egypt. Why in children now and not in adults? We need to see if there are sub-clinical cases in the community." He added that if the research did find such cases, they would be the first to be discovered anywhere in the world.
Though he stressed that there was still no evidence of the disease passing from person to person, other experts are also becoming alarmed. Professor Robert Webster, of St Jude Children's Research Hospital in Memphis, Tennessee – who is the world's leading authority on the disease – told The Independent on Sunday that, while he himself had not seen firm data, the WHO in Egypt was raising "a very, very important issue" which should receive "maximum attention". He added: "I hope to hell they are wrong. If this damn thing becomes less pathogenic, it will become more transmissible."
And Professor John Oxford, of Queen Mary, University of London, said that any evidence that H5N1 was becoming less deadly would be serious, as the greatest cause for concern was the disease's ability to spread.
Even a much less virulent strain of the bichito could result in a devastating pandemic. Studies show that an outbreak that killed as few as 5 per cent of those it infected could still cause hundreds of millions of deaths around the world.

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