Hipotesis: ¿es el COVID-19 una reacción alergica al SARS-COV2?

Kbkubito

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Bonita argumentación. Me gustaría poder hacer lo mismo con estudio de sujetos sometidos a ambientes cargados de partículas resultantes de la combustión del diesel, a ver q sale.
 

lolomondo

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Bonita argumentación. Me gustaría poder hacer lo mismo con estudio de sujetos sometidos a ambientes cargados de partículas resultantes de la combustión del diesel, a ver q sale.
Bien otro al ignore, lo ponéis fácil.
Buena herramienta creo Calopez
 

El Ariki Mau

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COVID-19 Hyperinflammation: What about Neutrophils?

EditorHeleneF. Rosenberg, National Instituteof Allergy and Infectious Diseases
24 June 2020

Parrafos selectos

The possible role of neutrophils in COVID-19 inflammation needs to be studied further.

Therole of neutrophils in viral infections of the upper respiratory tract and theirpossible importance in therapeutic strategies is not entirely clarified (8). They areinvolvedin early antiviral defense (9), but through degranulation and lysis, they can becytotoxicduring severe pneumonia, including from coronaviruses (10), and can alsoaggravatelung inflammation caused by influenza virus (11,12). Neutrophil hyperin-flammationis also likely in other severe viral infections such as hepatitis (8). In currentCOVID-19literature, an increased peripheral neutrophil-to-lymphocyte ratio is observedin severe cases and is likely associated with unfavorable prognosis (13). The mecha-nismsbehind this are not understood, and not much is known regarding neutrophilactivity in SARS-CoV-2-infected lungs. COVID-19 lung damage in some patients mightinvolve dysregulated neutrophil activity.

Moreover, it is perhaps worth noting that some currentlyinvestigatedCOVID-19 therapeutic options include hydroxychloroquine, azithromycin,and colchicine. All three have known antineutrophil effects.

Neutrophilrecruitment and related activity might exacerbate COVID-19 immuno-pathology. In contrast to universal immunosuppression, specific inflammatory path-ways could be targeted in COVID-19 hyperinflammation. These approaches can be alsocombined with antivirals. For instance, oseltamivir (Tamiflu) was recently shown toreduce neutrophil lung recruitment when combined with CXCR2 antagonists in influ-enza virus-infected mice (19). Moreover, it is perhaps worth noting that some currentlyinvestigatedCOVID-19 therapeutic options include hydroxychloroquine, azithromycin,and colchicine. All three have known antineutrophil effects. Finally, it is important tohighlight that this paper utilized publicly available bioinformatics tools to analyze alimited number of high-throughput gene expression data sets fromin vitroandin vivoSARS-CoV-2 infections. The likely involvement of neutrophil signatures and relatedinflammatory pathways presented here is unbiased and should be used with caution togenerate hypotheses for future experimental and translational studies. Interestingly,after this manuscript was submitted for consideration, the likely pathological role oflung neutrophil activity (formation of extracellular traps) in COVID-19 clinical compli-cations was published (20). More experimental and clinical work is needed to validatethesefindings and to inform possible anti-inflammatory interventions for severe cases.The immunopathological mechanisms driving COVID-19 are unclear, are continuouslyupdated, and will evolve drastically in the future.
 
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El exclavizador de mentes

Será en Octubre
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Ubicación
donde nacen las ideas
mientras el tercero, que no tenía activación inmunológica, no se asociaba con síntomas específicos o características clínica.

volvemos a lo mismo, estamos ya en Julio
a ver si va a ser que los asintomaticos nunca se han pillado el virus...

mode cachondo off]
 

piru

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vacunaciónpaísmuertospoblaciónmuertos
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